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Reagents and tools table Methods and protocols Mice All experiments were performed with 6- to 14-week-old female mice that were kept under specific pathogen-free conditions with water and food ad libitum

There was a trend towards a more robust correlation between S100B in serum and S100B-creatinine ratio

Treatment with FOXO4-DRI at 25 M in serum-limited senescent fibroblast and keloid organ culture models promoted apoptosis, decreased G0/G1 phase cells, and induced p53-pS15 nuclear exclusion confirmed by Annexin V-FITC/PI apoptosis assays and TUNEL staining of keloid organ cultures at days 3, 7, and 10